Influence of Melanosome Dynamics on Melanoma Drug Sensitivity
نویسندگان
چکیده
منابع مشابه
Influence of melanosome dynamics on melanoma drug sensitivity.
BACKGROUND Malignant melanomas are intrinsically resistant to many conventional treatments, such as radiation and chemotherapy, for reasons that are poorly understood. Here we propose and test a model that explains drug resistance or sensitivity in terms of melanosome dynamics. METHODS The growth and sensitivity to cisplatin of MNT-1 cells, which are melanotic and enriched with mature stage I...
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15 صفحه اولMultidrug resistance decreases with mutations of melanosomal regulatory genes.
Whereas resistance to chemotherapy has long impeded effective treatment of metastatic melanoma, the mechanistic basis of this resistance remains unknown. One possible mechanism of drug resistance is alteration of intracellular drug distribution either by drug efflux or sequestration into intracellular organelles. Melanomas, as well as primary melanocytes from which they arise, have intracellula...
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ژورنال
عنوان ژورنال: JNCI: Journal of the National Cancer Institute
سال: 2009
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/djp259